An EC 1.3.99.* (oxidoreductase acting on donor CH-CH group with other acceptors) inhibitor that interferes with the action of phytoene desaturase (zeta-carotene-forming), EC 1.3.99.29, an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene (zeta-carotene) via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene.
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| AR protein | Homo sapiens (human) | Potency | 31.0721 | 4 | 5 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 76.9197 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0024 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| ClpP | Bacillus subtilis | Potency | 31.6228 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 24.3118 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 24.0058 | 4 | 4 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 10.9622 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 38.8810 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 71.4508 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 64.7528 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 43.2331 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 61.0684 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 48.5084 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 13.6715 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 61.0684 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.4827 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 43.6252 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 43.6252 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 68.5896 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 44.2696 | 2 | 4 |